1,000-Year-Old Onion And Garlic Remedy Kills Antibiotic-Resistant Biofilms in The Lab - Latest Govt Exam
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1,000-Year-Old Onion And Garlic Remedy Kills Antibiotic-Resistant Biofilms in The Lab

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As deadly bacteria grow ever more resistant to modern antibiotics, some researchers have turned to ancient medical manuscripts for clues. And it looks like a medieval salve dating back 1,000 years might succeed where many modern antibiotics are starting to fail.

 

The “ancientbiotic”, as the researchers are calling it, was found in one of the earliest known medical textbooks from medieval England, known as Bald’s Leechbook

While many of the remedies included in this tome have not exactly aged well – including a salve to stop goblins visiting in the night – others, like ‘Bald’s eyesalve’, have stood up better to modern scrutiny. 

Building on previous research, scientists have shown this mix of natural ingredients – garlic, onion or leek, cow bile, and wine – may very well have powerful antiseptic properties. In fact, it appears to work against a panel of dangerous bacteria that have grown resistant to multiple modern drugs.

After brewing 75 batches of Bald’s eyesalve, including 15 with onion and 15 with leek (just to be absolutely sure about the Old English translation), researchers put the ancient recipe to the test. 

In the past, the recipe for this eyesalve has been shown to kill Staphylococcus aureus, the bacterium that causes golden staph. Now, a new study led by Jessica Furner-Pardoe from the University of Warwick backs those results up: Even when the bacteria formed particularly sturdy structures known as biofilms, the salve was effective.

 

S. aureus are particularly resistant bacteria, in large part because they can form biofilms, or, as one study put it: “slime-enclosed aggregates of sessile bacteria… irreversibly attached to surfaces.” That’s what makes resistant staph so dangerous.

Once these clusters of microorganisms set up shop, it’s incredibly difficult to get an antimicrobial agent in there. Breaking up the biofilm requires concentrations of antibiotics a hundred to a thousand times greater than would be necessary with free-floating forms. In extreme cases, it may even require amputation to avoid blood poisoning.

If this new research is right, however, there’s something in Bald’s eyesalve that biofilms can’t handle.

Even better, the salve appears to work against similarly resistant bacteria, including Acinetobacter baumanii, Stenotrophomonas maltophilia, S. epidermidis and S. pyogenes  – all of which can infect wounds, form biofilms, and grow resilient to antibiotics. 

“We think it has particular promise for treating diabetic foot infections,” University of Warwick microbiologist Freya Harrison told CNN. 

“They are the ultimate, super-resistant biofilm infection. They are a huge health and economic burden. They really can become untreatable.” 

 

But there’s a catch: the salve’s ingredients work best as an antimicrobial agent only in the remedy’s final form. When researchers separated or purified each element, they were not nearly as effective at killing bacterial strains.

The authors think this might be why herbal remedies haven’t stood up to scientific scrutiny thus far. In drug development and research, it’s common to isolate single compounds, and yet historically, medicine was more about combining natural matter, bouncing properties off one another.

“Thus, when considering natural products as a potential source of anti-biofilm agents, we must consider the possibility that any efficacy they may possess could rely on creating a cocktail of different products,” the authors write

“Understanding the relationship between combinations of natural products and antimicrobial activity may generate a novel way to create new antibiotics from botanicals.”

In this new study, for instance, wine showed little antimicrobial activity on its own, for either free-floating bacteria or biofilms. 

But that doesn’t mean it was entirely worthless. When the authors removed wine from the salve’s recipe, there was a large drop in activity against S. aureus biofilms, which suggests it has some important antimicrobial properties. 

In a similar way, the onion and bile showed little antibacterial activity when tested alone, but when removed from the whole remedy, it really showed. 

Whether or not Bald’s eye salve actually works in a clinical setting is up for further investigation, but the mixture didn’t show damage to human cells or mice in the lab, indicating it could be safe to pursue more studies. 

“Most antibiotics that we use today are derived from natural compounds, but our work highlights the need to explore not only single compounds but mixtures of natural products for treating biofilm infections,” says Harrison.

“We think that future discovery of antibiotics from natural products could be enhanced by studying combinations of ingredients, rather than single plants or compounds.”

The study was published in Scientific Reports.

 

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Women in the newsroom: Why South Africa leads the way

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Mahlatse Mahlase is group editor-in-chief of Eyewitness News, a major broadcaster in South Africa. It’s a role she would have been unlikely to fill 30 years ago, under the apartheid regime, whose hierarchy put Black women on a bottom tier.

But no matter where you look in the world, women’s leadership in the news media has lagged – and still does. South Africa, in fact, is a relative success story. Today, women lead nearly half of the country’s major publications and broadcasters, according to a recent analysis by Oxford University. That puts it ahead of the United States, the United Kingdom, and even countries held up as models of gender parity, like Finland.

Yet South African women’s gains have been especially hard-won, and incomplete. Women hold few of journalism’s purse strings, for instance. 

Ms. Mahlase says she has reflected on representation through a new prism since she gave birth seven months ago to her first child, a boy. 

“I want my son to grow up in a world where he has female bosses,” she says. “I want him to grow up listening to women experts on the radio, hearing them as contributors to changing the world and not just as victims of an unfair system.”

Johannesburg

Nwabisa Makunga can point to the exact moment she knew she would become a journalist.

It was April 1993 and she was 11 years old, watching the TV broadcast of the funeral of assassinated anti-apartheid leader Chris Hani with her family in their living room. The presenter was a Black reporter named Noxolo Grootboom, and her powerful tribute to Mr. Hani brought Ms. Makunga’s parents to tears.

“She was a woman who looked like me, who spoke like me, telling the story of a man who had been so important to people from my community,” she recalls. “I said to myself – this is what I’m going to do. I’m going to be like Noxolo, and I’m going to tell stories.”

Three decades later, Ms. Makunga is the editor-in-chief of the Sowetan, one of South Africa’s most-circulated daily newspapers. She is part of a generation of women who have risen through the ranks to take leadership of many of the country’s most important news outlets. Today, these women – most of them Black, Asian, and multiracial – lead nearly half the country’s major publications and broadcasters, according to a recent analysis by Oxford University. That makes the country a global leader for women’s leadership in the media, putting it ahead of the United States, the United Kingdom, and even countries held up as models of gender parity, like Finland.

And the achievement is doubly remarkable in South Africa, where only a generation ago the entire country was run largely by white men. Editors like Ms. Makunga grew up not only with few role models who looked like them, but also in a world where the media was used as a weapon of the apartheid regime, premised on white supremacy – enforcing a hierarchy in which they were the bottom tier.

Alexander Joe/AFP/Getty Images/File

A vendor sells a Daily Sun edition honoring former South African President Nelson Mandela’s birthday on July 18, 2013. The country’s transition to democracy opened up opportunities for many of today’s journalists.

Hard-won gains

Even after apartheid formally ended, these editors came up in newsrooms where its effects lingered. They were told their accents were “too African,” or their looks “too tempting.” Even as the newsrooms around them began to change from mostly white to mostly not, they still found themselves edged out of the pub trips and golf games where their male colleagues networked their way to the top.

“Make no mistake: Those statistics changing are the result of a fight,” says Mahlatse Mahlase, group editor-in-chief of Eyewitness News, a major breaking-news broadcaster. Women in South Africa’s newsrooms “have fought racism and they’ve also fought the patriarchy. The discrimination came from every side.”

Although they’ve now arrived, many of these same leaders note that South Africa’s media transformation remains incomplete. Women hold few of journalism’s purse strings, for instance. Just 19% of the board members at media companies here are female, according to a 2018 academic study of women in the media called “Glass Ceilings.” The vast majority of the country’s major media houses have a male CEO.

And while the proportion of Black, Asian, and multiracial women in the top echelons of South African media companies has grown from 6% in 2006 to 30% in 2018, that number still lags, in a country where they represent 46% of the population, according to the Glass Ceilings survey. Once they get there, meanwhile, they’re often placed under intense scrutiny and pressure.

“When men get to the top of their profession, they’re celebrated. When women get there, particularly Black women, there’s backlash, there’s trolling, there’s bullying,” says Glenda Daniels, an associate professor of media studies at the University of the Witwatersrand in Johannesburg and the co-author of the Glass Ceilings study. She uses the term “Black” as it is frequently applied in South Africa, to describe anyone who is not white. “Women at the top find they’re often exhausted just proving over and over that they deserve to be in the room.”

“Newsrooms figured out they needed to mimic what was happening in society so they wouldn’t end up on the wrong side of history.” – Mapula Nkosi, editor of the Daily Sun

Coming up the ladder

In 1994, the same year Nelson Mandela took the oath as South Africa’s first Black president, an ambitious young reporter named Mapula Nkosi walked into the Johannesburg newsroom of the Weekly Mail, which made its name opposing apartheid, to begin her career as a cadet reporter.

When she looked up the ranks, she says, she saw only men. But all around her, the country had a new buzzword: transformation. The process was often fuzzy, but the objective was clear: The structures that ruled the country should look more like the people who lived in it.

“Those newsrooms figured out they needed to mimic what was happening in society so they wouldn’t end up on the wrong side of history,” says Ms. Nkosi, now the editor of the Daily Sun, the country’s most-circulated daily newspaper. “The whole time I was coming up I had people on one side of me saying, ‘We don’t understand why you’re in this position,’ and people on the other side saying, ‘We are so excited to see where you go.’”

Those competing forces followed many of South Africa’s women journalists through their rise. Each time they pulled themselves up another rung on the ladder, they heard whispers – that they only got this job because leadership wanted a woman, that they’d never make it.

But when they did, the conversation changed.

“When you do well, you become almost genderless,” says Paula Fray, a media consultant and the first woman to edit the Saturday Star, a major South African newspaper. “But if you don’t do well, then your failings represent your whole gender.”

Meanwhile, women leaders in the newsroom “carry the added responsibility of making these environments more welcoming for women,” says Mary Papayya, a veteran journalist and editor who now sits on the board of the South African Broadcasting Corp. That, she notes, is a particularly difficult task at a time when many outlets have seen their budgets slashed and are now contending with a pandemic that has made news reporting both more dangerous and less lucrative.

And the fight for change goes beyond who sits in the corner office. In South Africa, like many countries, men are disproportionately both the experts and subjects of news stories. A recent analysis of the South African media’s coverage of the COVID-19 pandemic by the organization Media Monitoring Africa, for instance, found that 80% of those quoted in stories about the virus were men.

Ms. Mahlase, the radio news editor, says she sees these kinds of statistics through a new prism since she gave birth seven months ago to her first child, a boy. 

“I want my son to grow up in a world where he has female bosses,” she says. “I want him to grow up listening to women experts on the radio, hearing them as contributors to changing the world and not just as victims of an unfair system.”

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Environment

Women in the newsroom: Why South Africa leads the way

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Mahlatse Mahlase is group editor-in-chief of Eyewitness News, a major broadcaster in South Africa. It’s a role she would have been unlikely to fill 30 years ago, under the apartheid regime, whose hierarchy put Black women on a bottom tier.

But no matter where you look in the world, women’s leadership in the news media has lagged – and still does. South Africa, in fact, is a relative success story. Today, women lead nearly half of the country’s major publications and broadcasters, according to a recent analysis by Oxford University. That puts it ahead of the United States, the United Kingdom, and even countries held up as models of gender parity, like Finland.

Yet South African women’s gains have been especially hard-won, and incomplete. Women hold few of journalism’s purse strings, for instance. 

Ms. Mahlase says she has reflected on representation through a new prism since she gave birth seven months ago to her first child, a boy. 

“I want my son to grow up in a world where he has female bosses,” she says. “I want him to grow up listening to women experts on the radio, hearing them as contributors to changing the world and not just as victims of an unfair system.”

Johannesburg

Nwabisa Makunga can point to the exact moment she knew she would become a journalist.

It was April 1993 and she was 11 years old, watching the TV broadcast of the funeral of assassinated anti-apartheid leader Chris Hani with her family in their living room. The presenter was a Black reporter named Noxolo Grootboom, and her powerful tribute to Mr. Hani brought Ms. Makunga’s parents to tears.

“She was a woman who looked like me, who spoke like me, telling the story of a man who had been so important to people from my community,” she recalls. “I said to myself – this is what I’m going to do. I’m going to be like Noxolo, and I’m going to tell stories.”

Three decades later, Ms. Makunga is the editor-in-chief of the Sowetan, one of South Africa’s most-circulated daily newspapers. She is part of a generation of women who have risen through the ranks to take leadership of many of the country’s most important news outlets. Today, these women – most of them Black, Asian, and multiracial – lead nearly half the country’s major publications and broadcasters, according to a recent analysis by Oxford University. That makes the country a global leader for women’s leadership in the media, putting it ahead of the United States, the United Kingdom, and even countries held up as models of gender parity, like Finland.

And the achievement is doubly remarkable in South Africa, where only a generation ago the entire country was run largely by white men. Editors like Ms. Makunga grew up not only with few role models who looked like them, but also in a world where the media was used as a weapon of the apartheid regime, premised on white supremacy – enforcing a hierarchy in which they were the bottom tier.

Alexander Joe/AFP/Getty Images/File

A vendor sells a Daily Sun edition honoring former South African President Nelson Mandela’s birthday on July 18, 2013. The country’s transition to democracy opened up opportunities for many of today’s journalists.

Hard-won gains

Even after apartheid formally ended, these editors came up in newsrooms where its effects lingered. They were told their accents were “too African,” or their looks “too tempting.” Even as the newsrooms around them began to change from mostly white to mostly not, they still found themselves edged out of the pub trips and golf games where their male colleagues networked their way to the top.

“Make no mistake: Those statistics changing are the result of a fight,” says Mahlatse Mahlase, group editor-in-chief of Eyewitness News, a major breaking-news broadcaster. Women in South Africa’s newsrooms “have fought racism and they’ve also fought the patriarchy. The discrimination came from every side.”

Although they’ve now arrived, many of these same leaders note that South Africa’s media transformation remains incomplete. Women hold few of journalism’s purse strings, for instance. Just 19% of the board members at media companies here are female, according to a 2018 academic study of women in the media called “Glass Ceilings.” The vast majority of the country’s major media houses have a male CEO.

And while the proportion of Black, Asian, and multiracial women in the top echelons of South African media companies has grown from 6% in 2006 to 30% in 2018, that number still lags, in a country where they represent 46% of the population, according to the Glass Ceilings survey. Once they get there, meanwhile, they’re often placed under intense scrutiny and pressure.

“When men get to the top of their profession, they’re celebrated. When women get there, particularly Black women, there’s backlash, there’s trolling, there’s bullying,” says Glenda Daniels, an associate professor of media studies at the University of the Witwatersrand in Johannesburg and the co-author of the Glass Ceilings study. She uses the term “Black” as it is frequently applied in South Africa, to describe anyone who is not white. “Women at the top find they’re often exhausted just proving over and over that they deserve to be in the room.”

“Newsrooms figured out they needed to mimic what was happening in society so they wouldn’t end up on the wrong side of history.” – Mapula Nkosi, editor of the Daily Sun

Coming up the ladder

In 1994, the same year Nelson Mandela took the oath as South Africa’s first Black president, an ambitious young reporter named Mapula Nkosi walked into the Johannesburg newsroom of the Weekly Mail, which made its name opposing apartheid, to begin her career as a cadet reporter.

When she looked up the ranks, she says, she saw only men. But all around her, the country had a new buzzword: transformation. The process was often fuzzy, but the objective was clear: The structures that ruled the country should look more like the people who lived in it.

“Those newsrooms figured out they needed to mimic what was happening in society so they wouldn’t end up on the wrong side of history,” says Ms. Nkosi, now the editor of the Daily Sun, the country’s most-circulated daily newspaper. “The whole time I was coming up I had people on one side of me saying, ‘We don’t understand why you’re in this position,’ and people on the other side saying, ‘We are so excited to see where you go.’”

Those competing forces followed many of South Africa’s women journalists through their rise. Each time they pulled themselves up another rung on the ladder, they heard whispers – that they only got this job because leadership wanted a woman, that they’d never make it.

But when they did, the conversation changed.

“When you do well, you become almost genderless,” says Paula Fray, a media consultant and the first woman to edit the Saturday Star, a major South African newspaper. “But if you don’t do well, then your failings represent your whole gender.”

Meanwhile, women leaders in the newsroom “carry the added responsibility of making these environments more welcoming for women,” says Mary Papayya, a veteran journalist and editor who now sits on the board of the South African Broadcasting Corp. That, she notes, is a particularly difficult task at a time when many outlets have seen their budgets slashed and are now contending with a pandemic that has made news reporting both more dangerous and less lucrative.

And the fight for change goes beyond who sits in the corner office. In South Africa, like many countries, men are disproportionately both the experts and subjects of news stories. A recent analysis of the South African media’s coverage of the COVID-19 pandemic by the organization Media Monitoring Africa, for instance, found that 80% of those quoted in stories about the virus were men.

Ms. Mahlase, the radio news editor, says she sees these kinds of statistics through a new prism since she gave birth seven months ago to her first child, a boy. 

“I want my son to grow up in a world where he has female bosses,” she says. “I want him to grow up listening to women experts on the radio, hearing them as contributors to changing the world and not just as victims of an unfair system.”

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Trump Administration Penalizes Chinese Officials for Hong Kong Crackdown

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WASHINGTON — The Trump administration on Friday imposed sanctions on 11 senior Chinese Communist Party officials and their Hong Kong allies, including chief executive Carrie Lam, over their role in cracking down on political dissent in the southern Chinese territory.

These are the first sanctions against officials from China and Hong Kong over suppression of pro-democracy protests and dissent in the territory. They are being imposed as actions following an executive order President Trump signed last month seeking to punish China for its repression in Hong Kong.

“The United States stands with the people of Hong Kong and we will use our tools and authorities to target those undermining their autonomy,” Steven T. Mnuchin, the Treasury secretary, said in a statement.

The action is another in a series of measures the Trump administration has taken in recent months to ratchet up pressure on Beijing. Last month, the administration imposed sanctions on the Chinese government, including a senior member of the Communist Party, over human rights abuses against the largely Muslim Uighur minority.

Beijing announced in June that it was imposing a new national security law in Hong Kong to grant security agencies expansive powers to crack down on dissent.

Since then, American officials have debated how to get Beijing to roll back the law or how to penalize the action.

Last month, Mr. Trump signed an executive order ending the special status that the United States grants Hong Kong in diplomatic and trade relations, saying Hong Kong was no longer an autonomous entity, and officials are now beginning to treat the territory like mainland China.

Some administration officials had wanted Mr. Trump to announce during the signing that his government was imposing sanctions on Ms. Lam and other officials in China and Hong Kong. The president declined to do so then.

The current flurry of actions against China dovetails with a core part of Mr. Trump’s campaign strategy. His campaign aides are trying to show Mr. Trump is hitting China hard in order to shift the national conversation from his failures on managing the coronavirus pandemic and the economy.

The initial virus outbreak began in central China, and Mr. Trump has blamed Chinese officials for failing to contain it, though he also praised China’s leader, Xi Jinping, for efforts this winter.

Some of the administration’s China hawks are trying to set the two nations on a course for long-term confrontation and ensure that relations remain in a state of open rivalry even if Democratic candidate Joseph R. Biden Jr. wins the November election.

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